Wnt1/bcatenin injury response activates the epicardium and cardiac fibroblasts to promote cardiac repair

نویسندگان

  • Jinzhu Duan
  • Costin Gherghe
  • Dianxin Liu
  • Eric Hamlett
  • Luxman Srikantha
  • Laurel Rodgers
  • Jenna N Regan
  • Mauricio Rojas
  • Monte Willis
  • Andrew Leask
  • Mark Majesky
  • Arjun Deb
چکیده

Jinzhu Duan, Costin Gherghe, Dianxin Liu, Eric Hamlett, Luxman Srikantha, Laurel Rodgers, Jenna N Regan, Mauricio Rojas, Monte Willis, Andrew Leask, Mark Majesky and Arjun Deb* Department of Medicine, McAllister Heart Institute and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA, Department of Cell and Molecular Physiology, McAllister Heart Institute and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA, Department of Genetics, McAllister Heart Institute and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA, Department of Pathology and Laboratory Medicine, McAllister Heart Institute and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA, Division of Oral Biology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada, Division of Cardiology, Department of Pediatrics, Seattle Children’s Research Institute, University of Washington School of Medicine, Seattle, WA, USA and Curriculum in Genetics and Molecular Biology, McAllister Heart Institute and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA

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Wnt1/βcatenin injury response activates the epicardium and cardiac fibroblasts to promote cardiac repair.

Wnts are required for cardiogenesis but the role of specific Wnts in cardiac repair remains unknown. In this report, we show that a dynamic Wnt1/βcatenin injury response activates the epicardium and cardiac fibroblasts to promote cardiac repair. Acute ischaemic cardiac injury upregulates Wnt1 that is initially expressed in the epicardium and subsequently by cardiac fibroblasts in the region of ...

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تاریخ انتشار 2013